Differences between ceftizoxime and its stereoisomer in antibacterial activity and affinity for penicillin-binding proteins
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چکیده
منابع مشابه
Htibacterial activity ceftizoxime and its comparison with that of chloramphenicol, penicillin G, cephalexin, cefzoline and cephalothin
This study compares the inhibitory effect of ceftizoxime with that of penicillin G, chloramphenicol, cephalothin, cephalexin and cefzoline on Klebsiella pneumoniae, Proteus mirabilis, pseudomonas ruginosa, staphylococcus aureus, staphylococcus epidermidis, staphylococcus saprophyticus and Escherichia coli. The in vitro inhibitory effect of ceftizoxime on P. mirabilis, P. Aeruginosa, S.prophytic...
متن کاملOn the relationships between molecular conformation, affinity towards penicillin-binding proteins, and biological activity of penicillin G-sulfoxide.
The binding capacity of penicillin G-sulfoxide towards the penicillin-binding proteins (PBP) of Staphylococcus aureus H was studied. The sulfoxide and its parent compound, penicillin G, differ only in two aspects, the sulfur-bound oxygen and an altered conformation of the five-membered thiazolidine-ring system. These minor alterations of the penicillin structure resulted in a drastical decrease...
متن کاملIn vitro activity of sanfetrinem and affinity for the penicillin-binding proteins of Streptococcus pneumoniae.
Against penicillin-susceptible pneumococci, the activity of sanfetrinem was similar to those of penicillin, amoxicillin, cefotaxime, imipenem, and meropenem, while against penicillin-resistant strains, sanfetrinem and the carbapenems exhibited superior activity (MICs at which 90% of strains are inhibited, < or =1 microg/ml). PBP 1a in the penicillin-susceptible strain and PBP 1a and PBP 2b in t...
متن کاملAbout the affinity of cefotaxime and its anti isomer for the penicillin-binding proteins.
Recently COSTA and BOTTA" published a study of the interactions with penicillin-binding proteins (PBPs) of Escherichia coli of cefotaxime, its anti isomer and the analogue without the oxime function. They concluded that the differences in antibacterial activities of the compounds was much related to differences in their ability to penetrate the outer cell layers, rather than their affinity for ...
متن کاملPenicillin-bin Ding Proteins in Bacillus Subtilis the Effects on Penicillin-binding Proteins and the Antibacterial Activities of 3-lactams
Several,3-lactams were investigated on the affinity for the penicillin-binding proteins (PBPss) and the antibacterial activity in Bacillus subtilis. The 19-lactams uch as ampicillin, PS-5, methicillin and SCE-963, which had high affinities for PBP-2 showed strong antibacterial activities and the 3-lactams such as cephamycin C, Y-G19Z-GG and Y-G19Z-G, which had high affinities for PBP-1 but low ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1981
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.19.3.393